Hepatocellular carcinoma is a common and highly malignant disease.As a currently designated systemic chemotherapeutic agent for advanced Hepatocellular carcinoma, sorafenib has been confronted with dilemma of drug-resistance caused by tumor hypoxia, which hinders the therapeutic efficacy of the drug.Based on this, a multifunctional mesoporous polyd
This report represents the first description of tricuspid valve dysplasia in a Basset hound.We evaluated clinical signs, ECG abnormalities and echocardiographic findings related to tricuspid valve dysplasia in a 6 month Basset Hound.A specific protocol of cardiologic examination was performed every time the Peeling patient was evaluated.This protoc
The differentiated cell types of the epithelial and mesenchymal tissue compartments of the mature ureter of the mouse arise in a precise temporal and spatial sequence from uncommitted precursor cells of the distal ureteric bud epithelium and its surrounding mesenchyme.Previous genetic efforts identified a member of the Hedgehog (HH) family of secre
Oncolytic viruses would ideally be of use for systemic therapy to treat disseminated cancer.To do this safely, this may require multiple layers of cancer specificity.The pharmacology and specificity of oncolytic adenoviruses can be modified by (1) physical retargeting, (2) physical detargeting, (3) chemical shielding, or (4) by modifying the abilit
Thangka murals are precious cultural heritage for Tibetan history, literature, and art.Digital line drawing of Thangka murals plays a vital role not only as an abstracted expression of Thangka for art appreciation but also as a fundamental digital resource for Thangka protection.Digital Thangka line drawing can be categorized as image edge detectio